What do effector cells do




















Both neutralizing and non-neutralizing human H7N9 influenza vaccine-induced monoclonal antibodies confer protection. Cell Host Microbe. Fc functional antibodies in humans with severe H7N9 and seasonal influenza. JCI Insight. Fc receptor but not complement binding is important in antibody protection against HIV.

Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in vivo activity. A role for Fc function in therapeutic monoclonal antibody-mediated protection against ebola virus. Systematic analysis of monoclonal antibodies against ebola virus GP defines features that contribute to protection. Acosta EG, Bartenschlager R. Paradoxical role of antibodies in dengue virus infections: considerations for prophylactic vaccine development. Expert Rev Vacc.

A role for immune complexes in enhanced respiratory syncytial virus disease. J Exp Med. Immune responses and disease enhancement during respiratory syncytial virus infection.

Clin Microbiol Rev. Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease. Activation of NK cell cytotoxicity. Mol Immunol. Antibody therapy of cancer. Nat Rev Cancer. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J Virol. Immune-correlates analysis of an HIV-1 vaccine efficacy trial.

Immune correlates of vaccine protection against HIV-1 acquisition. Sci Transl Med. HIV-1 gpspecific antibody-dependent cell-mediated cytotoxicity correlates with rate of disease progression. J Immunol. PubMed Abstract Google Scholar. Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers.

Specific antibody-dependent cellular cytotoxicity responses associated with slow progression of HIV infection. PLoS Pathog. Generation and protective ability of influenza virus-specific antibody-dependent cellular cytotoxicity in humans elicited by vaccination, natural infection, and experimental challenge. Antibody-dependent cellular cytotoxicity and influenza virus.

Curr Opin Virol. Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections. Vaccine-induced anti-HA2 antibodies promote virus fusion and enhance influenza virus respiratory disease.

Relationship of preexisting influenza hemagglutination inhibition, complement-dependent lytic, and antibody-dependent cellular cytotoxicity antibodies to the development of clinical illness in a prospective study of A H1N1 pdm09 Influenza in children.

Viral Immunol. Antibody-dependent cell-mediated cytotoxicity epitopes on the hemagglutinin head region of pandemic H1N1 influenza virus play detrimental roles in H1N1-infected mice. Front Immunol. Antibodies from patients with dengue viral infection mediate cellular cytotoxicity.

Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replication. Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection.

Sci Rep. Hussell T, Openshaw PJ. J Gen Virol. Natural killer cells are involved in acute lung immune injury caused by respiratory syncytial virus infection. Med Microbiol Immunol. Severe human lower respiratory tract illness caused by respiratory syncytial virus and influenza virus is characterized by the absence of pulmonary cytotoxic lymphocyte responses. Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus. Pediatr Res.

Interleukin is associated with disease severity in viral bronchiolitis. Eur Respir J. Peripheral blood mononuclear cells from infants hospitalized because of respiratory syncytial virus infection express T helper-1 and T helper-2 cytokines and CC chemokine messenger RNA. Differential lower airway dendritic cell patterns may reveal distinct endotypes of RSV bronchiolitis.

Human antibody-dependent cell-mediated cytotoxicity against target cells infected with respiratory syncytial virus. Clin Exp Immunol. Antibody-dependent cell-mediated cytotoxicity against cells infected with respiratory syncytial virus: characterization of in vitro and in vivo properties.

Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Affinity-purified respiratory syncytial virus antibodies from intravenous immunoglobulin exert potent antibody-dependent cellular cytotoxicity. Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F ab' 2 components mediates reduced pulmonary inflammation in mice. Development of antibody-dependent cell-mediated cytotoxicity in the respiratory tract after natural infection with respiratory syncytial virus.

Infect Immun. Involvement of the complement system in the protection of mice from challenge with respiratory syncytial virus Long strain following passive immunization with monoclonal antibody 18A2B2.

Protection of mice against Human respiratory syncytial virus by wild-type and aglycosyl mouse-human chimaeric IgG antibodies to subgroup-conserved epitopes on the G glycoprotein. Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice.

Nat Commun. Influenza-specific antibody-dependent phagocytosis. Protection from cytomegalovirus viremia following glycoprotein B vaccination is not dependent on neutralizing antibodies. HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions. Antiviral antibodies target adenovirus to phagolysosomes and amplify the innate immune response.

Poorly neutralizing cross-reactive antibodies against the fusion loop of West Nile virus envelope protein protect in vivo via Fcgamma receptor and complement-dependent effector mechanisms.

Opsonization-enhanced phagocytosis of foot-and-mouth disease virus. Role of macrophages in early protective immune responses induced by two vaccines against foot and mouth disease. Antiviral Res. Activation of oxidative and arachidonic acid metabolism in neutrophils by respiratory syncytial virus antibody complexes: possible role in disease. Effect of respiratory syncytial virus-antibody complexes on cytokine IL-8, IL-6, TNF-alpha release and respiratory burst in human granulocytes.

An ultrastructural study of the interaction of human eosinophils with respiratory syncytial virus. Pediatr Allergy Immunol. The secreted G protein of human respiratory syncytial virus antagonizes antibody-mediated restriction of replication involving macrophages and complement. Borsos T, Rapp HJ. Complement fixation on cell surfaces by 19S and 7S antibodies. Complement is activated by IgG hexamers assembled at the cell surface.

Complement system part I - molecular mechanisms of activation and regulation. Complement system part II: role in immunity. Suppression of the immune response by a soluble complement receptor of B lymphocytes. Complement-dependent transport of antigen into B cell follicles. Complement protein C1q reduces the stoichiometric threshold for antibody-mediated neutralization of West Nile virus. A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus.

Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5. NPJ Vacc. Crossed immunoelectrophoresis for the detection of split products of the third complement in dengue hemorrhagic fever. Observations in patients' plasma. Am J Trop Med Hyg.

Alternative complement pathway deregulation is correlated with dengue severity. Activation of the complement system in human immunodeficiency virus infection: relevance of the classical pathway to pathogenesis and disease severity. Neutralizing and enhancing antibodies measured in complement-restored serum samples from HIVinfected individuals correlate with immunosuppression and disease. Appearance of complement components and immunoglobulins on nasopharyngeal epithelial cells following naturally acquired infection with respiratory syncytial virus.

J Med Virol. Comparison of fluorescent-antibody, neutralizing-antibody, and complement-enhanced neutralizing-antibody assays for detection of serum antibody to respiratory syncytial virus.

J Clin Microbiol. C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression.

Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins.

Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge. Nimmerjahn F, Ravetch JV. Fcgamma receptors: old friends and new family members. Anti-inflammatory actions of intravenous immunoglobulin. Annu Rev Immunol. Bolland S, Ravetch JV. Spontaneous autoimmune disease in Fc gamma RIIB-deficient mice results from strain-specific epistasis. Anti-HA glycoforms drive B cell affinity selection and determine influenza vaccine efficacy. Tyrosine-containing motif that transduces cell activation signals also determines internalization and antigen presentation via type III receptors for IgG.

J Clin Invest. Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with ILp70 production and immunity to antibody-coated tumor cells. Selective blockade of the inhibitory Fcgamma receptor FcgammaRIIB in human dendritic cells and monocytes induces a type I interferon response program. Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors.

Effect of respiratory syncytial virus and virus-antibody complexes on the oxidative metabolism of human neutrophils. Analysis of cells obtained by bronchial lavage of infants with respiratory syncytial virus infection. Arch Dis Child. Respiratory syncytial virus and neutrophil activation. Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes.

Lancet Infect Dis. Fc receptors in antibody-dependent enhancement of viral infections. Immunol Rev. Antibody-dependent enhancement of respiratory syncytial virus infection by sera from young infants. Clin Diagn Lab Immunol. Neutralizing and enhancing activities of human respiratory syncytial virus-specific antibodies. In vitro enhancement of respiratory syncytial virus infection by maternal antibodies does not explain disease severity in infants.

Respiratory syncytial virus RSV infects primary neonatal and adult natural killer cells and affects their antiviral effector function. Summary report: workshop on the potential risks of antibody-dependent enhancement in human HIV vaccine trials. Polack FP. Atypical measles and enhanced respiratory syncytial virus disease ERD made simple.

Association between the seasonal influenza vaccine and pandemic H1N1 illness during Spring-Summer four observational studies from Canada. PLoS Med.

Antibody-dependent enhancement of severe dengue disease in humans. Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus RSV or purified F glycoprotein and challenged with RSV months after immunization. Google Scholar. Immunization with low doses of recombinant postfusion or prefusion respiratory syncytial virus F primes for vaccine-enhanced disease in the cotton rat model independently of the presence of a Th1-Biasing GLA-SE or Th2-biasing alum adjuvant.

IgG subclasses and allotypes: from structure to effector functions. Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses. Jennewein MF, Alter G.

The immunoregulatory roles of antibody glycosylation. Trends Immunol. Serum immunoglobulin G antibody subclass responses to respiratory syncytial virus F and G glycoproteins after primary infection. Age related IgG subclass response to respiratory syncytial virus fusion protein in infected infants. IgG subclass distribution of antibodies to bacterial and viral antigens. Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.

Antibody-mediated internalization of infectious HIV-1 virions differs among antibody isotypes and subclasses. Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential. Bournazos S, Ravetch JV. Impaired Antibody-mediated protection and defective IgA B-cell memory in experimental infection of adults with respiratory syncytial virus.

Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults. Ontogenesis of the formation of secretory antibodies to respiratory syncytial RS virus. Epidemiol Infect. The development of respiratory syncytial virus-specific IgE and the release of histamine in nasopharyngeal secretions after infection. Evaluation of immunoglobulin E-specific antibodies and viral antigens in nasopharyngeal secretions of children with respiratory syncytial virus infections.

Welliver RC, Duffy L. The relationship of RSV-specific immunoglobulin E antibody responses in infancy, recurrent wheezing, and pulmonary function at age years. Pediatr Pulmonol. IgE anti-respiratory syncytial virus antibodies detected in serum of pediatric patients with asthma. Hum Immunol. Virus-specific IgE enhances airway responsiveness on reinfection with respiratory syncytial virus in newborn mice. The appearance of cell-bound IgE in respiratory-tract epithelium after respiratory-syncytial-virus infection.

Predictive value of respiratory syncytial virus-specific IgE responses for recurrent wheezing following bronchiolitis. J Pediatr. High serum IgE level in the children with acute respiratory syncytial virus infection is associated with severe disease.

Differential immunoglobulin G subclass antibody titers to respiratory syncytial virus F and G glycoproteins in adults. Serum immunoglobulin G antibody subclass response to respiratory syncytial virus F and G glycoproteins after first, second, and third infections.

Age-specific profiles of antibody responses against respiratory syncytial virus infection. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells.

Comparison of class and subclass antibody response to live and UV-inactivated RSV administered intranasally in mice.

Glycan variants of a respiratory syncytial virus antibody with enhanced effector function and in vivo efficacy. Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity. Nat Biotechnol. J Biol Chem. Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose. Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant.

Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer. Cancer Res. Preclinical studies on the mechanism of action and the anti-lymphoma activity of the novel anti-CD20 antibody GA Mol Cancer Ther. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Decoding the human immunoglobulin G-Glycan repertoire reveals a spectrum of Fc-receptor- and complement-mediated-effector activities.

J Autoimmun. Changes in IgG glycoform levels are associated with remission of arthritis during pregnancy. Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study. Arthritis Res Ther. Antigen-specific antibody glycosylation is regulated via vaccination.

Shim H. Dendritic cells are antigen-presenting cells APCs. Antigen is combined with major histocompatibility complex and presented on a dendritic cell to active T and B lymphocytes. An eosinophil is a type of immune cell leukocyte, or white blood cell. They help fight infection or cause inflammation. Granulocytes including eosinophils, neutrophils and basophils are a type of white blood cell that releases toxic materials, such as antimicrobial agents, enzymes, nitrogen oxides and other proteins, during an attack from a pathogen.

The primary effector cell of innate immunity; the first responders of the immune system. They interact with signals from other cells activating and inhibitory. Type of white blood cell that is involved with the immune system. T lymphocytes mature in the thymus and differentiate into cytotoxic, memory, helper and regulatory T cells. The T cells are grown and modified in a lab to include special receptors chimeric antigen receptor that can recognize and attack cancer cells.

Activated cytotoxic T cells can migrate through blood vessel walls and non-lymphoid tissues. They can also travel across the blood brain barrier.

Derived from activated cytotoxic T cells, memory T cells are long-lived and antigen-experienced. One memory T cell can produce multiple cytotoxic T cells. After activated cytotoxic T cells attack the pathogen, the memory T cells hang around to mitigate any recurrence. Helper T cells secrete cytokines that help B cells differentiate into plasma cells.

These cells also help to activate cytotoxic T cells and macrophages. Lymphocytes are immune cells found in the blood and lymph tissue. T and B lymphocytes are the two main types. Macrophages are large white blood cells that reside in tissues that specialize in engulfing and digesting cellular debris, pathogens and other foreign substances in the body.

Large white blood cells that reside in the blood stream that specialize in engulfing and digesting cellular debris, pathogens and other foreign substances in the body. Monocytes become macrophages. When immature myeloid cells cannot differentiate into mature myeloid cells, due to conditions like cancer, expansion of myeloid-derived suppressor cells occurs, and the T-cell response can be suppressed. A type of white blood cell, granulocyte, and phagocyte that aids in fighting infection. Neutrophils kill pathogens by ingesting them.

Phagocytes eat up pathogens by attaching to and wrapping around the pathogen to engulf it. Once the pathogen is trapped inside the phagocyte, it is in a compartment called a phagosome.

The phagosome will then merge with a lysosome or granule to form a phagolysosome, where the pathogen is killed by toxic materials, such as antimicrobial agents, enzymes, nitrogen oxides or other proteins. Tell us what you think about Healio.

Begin your journey with Learn Immuno-Oncology. Test your knowledge and determine where to start. Combination Immunotherapies References. Visit Healio. Your Module Progress. Module 1. Module Content. Thank you for participating in this module. Click below to download the certificate. Video Tutorials. Application Examples Clinical Studies. Circulating Tumor Cells.

Clinical Studies. FAQ pluriStrainer. Cell Types Monocytes. Effector T cells. NK cells. Sample Material Buffy Coat. Whole Blood. Other languages. Regulatory T cells Regulatory T T reg cells suppressor T cells are essential for the maintenance of immune tolerance. Helper T cells T helper cells T h cells help other leukocytes in immunologic processes, including maturation of B cells into plasma cells and memory B cells. Cytotoxic T cells Cytotoxic T cells T c cells, CTLs, T-killer cells, killer T cells destroy virus-infected cells and tumor cells, and are also implicated in transplant rejection.

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